RAF Typhoon fighter aircraft have joined forces with French warplanes in a coordinated attack against an subterranean weapons facility in Syria used by the IS group, according to the British defence ministry.
The facility, located using surveillance, was thought to be containing munitions and bombs, the statement said, and was located in hills just to the north of the historic site of Palmyra in central Syria.
"Our fighter planes employed Paveway IV guided bombs to strike a number of approach shafts leading to the depot... early reports indicate the strike was effective," officials stated.
There was no sign of any civilian casualties in the operation on Saturday evening and each participating jet returned to base without incident, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - referred to as ISIS - established jihadist rule over large swathes of Iraq and Syria until 2019.
"This action underscores British leadership, and determination to work closely with our partners, to eradicate any revival of Daesh and their violent and radical beliefs in the region," Britain's Defence Chief the minister said.
UK warplanes have performed surveillance missions over Syria to "forestall any efforts to regroup" of the group following its routing at the battle of Baghuz in 2019, the authorities noted.
"I must thank all the members of British forces involved in this mission for their expertise and their valour," he said. "They were among thousands of British troops deployed over the holidays. This operation, to eliminate militants who pose a risk to our security, highlights how our armed forces are prepared to act, continuously, ensuring Britain's security at home and influential overseas."
During December, the American forces conducted what it termed a "major assault" on Islamic State objectives in Syria, following an ambush claimed the lives of two US servicemembers and a local interpreter in Palmyra.
The United Nations reports Daesh still boasts an estimated 5,000 to 7,000 fighters in both countries.